Thursday, January 24, 2013

KCP* to showcase The Efficient Workplace | Suzanne Howe ...

Applying ?Lean? principles to help Health & Safety managers do their jobs more effectively will be the major focus for KIMBERLY-CLARK PROFESSIONAL* at the forthcoming IOSH 2013 trade show.

Exhibiting on Stand B60, KIMBERLY-CLARK PROFESSIONAL* will highlight the benefits of its Efficient Workplace programme, which has been designed to help companies in a range of industries eliminate hazards and strip out waste from their operations while enhancing their performance in the process.

At IOSH 2013, which takes place at London?s ExCel on 26-27 February 2013, KIMBERLY-CLARK PROFESSIONAL* will demonstrate to visitors how The Efficient Workplace initiative can help Health & Safety professionals achieve their objectives by highlighting the optimum way to select, dispense, use and store equipment and supplies in industrial environments.

Guided by well-established ?Lean? business principles, The Efficient Workplace is targeted at companies in the automotive, aerospace, food processing and metal manufacturing sectors.

The programme begins with a visit from a knowledgeable and experienced KIMBERLY-CLARK PROFESSIONAL* account manager, who will take the time to conduct a waste walk around the customer?s facility in order to gain a full understanding of their specific processes and priorities. During this site assessment, the account manager will advise Health & Safety representatives on any areas where there may be inefficiency or potential hazards and suggest targeted counter-measures.

Having identified waste within a customer?s processes, the account manager is able to recommend specific products and services that are designed especially for the particular needs of the company in question.

Alison Cook, End User Marketing Manager UK, Ireland & Benelux at KIMBERLY-CLARK PROFESSIONAL*, said: ?At the heart of The Efficient Workplace programme is the principle that an efficiently-run business is a safe business, and a safe business is an efficient business. It?s a unique approach that will enable Health & Safety professionals demonstrate to their colleagues and management just how valuable health & safety is in the profitable running of an industrial business.?

She continued: ?The programme helps companies identify hazards and waste and root them out using targeted, tailored solutions. It?s a unique approach to maximising safety and profitability based on finding the right solution for each individual company. It is about identifying the appropriate and most effective industrial supplies for a situation ? not simply the cheapest. Further, once the right solution is in place, we have the service capabilities to help our customers drive and maintain full compliance. In this way we can advise them on the best way to get a job done safely.?

KIMBERLY-CLARK PROFESSIONAL* offers Health & Safety managers full support at every stage, providing helpful and discreet advice as required. At the core of The Efficient Workplace are Lean principles that have been tried and tested over the past 100 years.

Alison Cook added: ?Although increasing efficiency is already a major focus for our customers, when we talk to them they often tell us that it really helps to have a second pair of credible eyes to spot areas where further improvement is possible. It saves them time, effort and ? ultimately ? money. It?s a great way of helping industrial manufacturers achieve their targets in their health & safety processes.?

She added: ?We speak our customers? language, and our account managers ? who all have industry knowledge ? use a highly consultative approach to identifying waste and hazards and suggesting ways to reduce or eliminate them. At KIMBERLY-CLARK PROFESSIONAL* we have used Lean principles in our own manufacturing processes for years, so we are steeped in experience and committed to helping our customers benefit, too.?

The Efficient Workplace programme has been developed as part of the KIMBERLY-CLARK PROFESSIONAL* brand promise to help all its customers create ?Exceptional Workplaces?.

?Exceptional Workplaces is our vision for the future ? a vision that is focused on delivering products and services that create workplaces that are healthier, safer and more productive,? said Alison Cook. ?The Efficient Workplace programme is one of the key platforms we have developed to enable us to achieve this mission. We look forward to meeting Health & Safety professionals at IOSH 2013 to tell them more about how this ground-breaking initiative could make their workplace a safer and more productive place.?

IOSH 2013 is the trade show of the Institution of Occupational Safety and Health. It takes place at London?s ExCel from 26-27 February 2013. KIMBERLY-CLARK PROFESSIONAL* will exhibit on stand B60.

Download this news release as a pdf

Source: http://www.suzannehowe.com/kcp-to-showcase-the-efficient-workplace/

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Wednesday, January 23, 2013

Keep on top of your business finances | Sansone Accounting & Tax

Keep on top of your business finances

Saving time in the operation of your business is key. Every hour you spend record-keeping is one hour less of? running your company.

Turning to Intuit?s Quickbooks Pro can help with records, company finances and other business items. More than 60 percent of business owners who have had Quickbooks Pro installed at their firm report saving at least one hour of time a week.

Our staff at Sansone Accounting & Tax can help you set up Quickbooks Pro for your business and answer any questions about the software that you may have. We will? walk you through the process and ensure all necessary items are in place before Quickbooks Pro is put into operation. We will help you get the system up and running and make sure everything is right to get your business finances centralized before labeling the job ?finished.? And we will remain a source of information for you ? even after the software is installed.

Small-business owners have been turning to Quickbooks Pro to make and record bank deposits. They have also been using the program to review reports, and track sales and expenses, adding to their business insight. Other uses for Quickbooks Pro include making payments, preparing tax documents and entering and tracking bills.

Our experts at Sansone can help you determine ways Quickbooks Pro can help your business and we will be with you throughout the installation and training process. We can show you how Quickbooks can help you improve your bottom line and keep you on top of your finances. Plus, we can give you insight on how the software can show you industry trends, allowing you to see how you stack up against similar companies.

Whether an attorney, the leader of a non-profit organization, a contractor or any other small-business leader, Quickbooks Pro has something to offer to help you get a better handle on your business finances ? and save you time and effort in the process.

It is easy to see why Quickbooks is the top-selling small business accounting software. It allows you to organize everything in one place, knocking time off everyday financial tasks. You can manage vendors and expenses, tracking and paying bills with just a few clicks of your mouse. The software also allows you to create and customize invoices, estimates and statements.

Sales, financial and tax reports can be summoned in just a computer click. Income and expense trends are evident as they are broken down by category. Get an overall status report of your business with the ?Company Snapshot? feature. Import data from a spreadsheet on the software which is now Windows 8 compatible.

As small businesses continue to play a growing role in the global economy, you need to be at the top of your game every single day to know the trends and not miss opportunities. Being in the driver?s seat of your small business, you can?t afford to fall behind the competition. Quickbooks Pro gives you the knowledge you need to make the right decisions for your business.

Keeping on top of sales reports, invoices, vendors and customers has never been easier. Couple the convenience of Quickbooks Pro, with the expertise of Sansone and put your business out in front of the competition. We can give you the road map to understanding your businesses strengths and weaknesses ? and how to make your way to success in this global economy.

Whether starting, growing or just looking to better operate your business, the Quickbooks Pro software can make a difference for your company. The software provides you with vital information about your business? revenue and expense.

A redesigned Quickbooks Pro tool bar helps you better navigate the site and puts more information at your fingertips. The software allows you to break down tasks the way your business does them. You do not have to change company procedures just to meet the demands of an inflexible software program. The toolbar allow you to create shortcuts, picking the things you want to see and blocking out things that are not of as much interest to you.

The redesigned software is more readable and more efficient for your business. Color-coded shortcuts lead you where you want to go, speeding your time in getting the numbers you are seeking.

The streamlined navigation in the newest version of the software makes it easier to access your data and recent transactions. Simplified customer forms enable you to spend more time running your business and less time handling your books.

Accomplish financial task quicker than you ever through possible ? through the technology of Quickbooks Pro and the expertise of Sansone.

Sansone Accounting & Tax is known for guiding clients through planning and preparation decisions to minimize tax liabilities. Whether it be Quickbooks Pro or new business taxes, we pride ourselves on being available to play a major role in supporting your financial, record-keeping and tax-planning issues. If there is anything we can help you with, please schedule an appointment with one of our certified public accountants by calling (815) 459-4300.

Source: http://sansonecpa.com/all-blog-post/quickbooks/keep-on-top-of-your-business-finances/

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What holds energy tech back? The infernal battery

FILE - In a Feb 27, 2002 file photo, Lew Urry holds up an original alkaline battery that was marketed in 1958, left, and a current battery in Westlake, Ohio. Urry, 76, who still works for Energizer Holdings Inc., developed the first commercially viable alkaline battery. It?s been nearly a quarter of a century since the last big jump in battery technology. As 21st century technology strains to be ever faster, cleaner and cheaper, the battery, an invention from more than 200 years ago keeps holding it back. (AP Photo/Tony Dejak, File)

FILE - In a Feb 27, 2002 file photo, Lew Urry holds up an original alkaline battery that was marketed in 1958, left, and a current battery in Westlake, Ohio. Urry, 76, who still works for Energizer Holdings Inc., developed the first commercially viable alkaline battery. It?s been nearly a quarter of a century since the last big jump in battery technology. As 21st century technology strains to be ever faster, cleaner and cheaper, the battery, an invention from more than 200 years ago keeps holding it back. (AP Photo/Tony Dejak, File)

This undated photo provided by the National Transportation Safety Board shows the burned auxiliary power unit battery from a JAL Boeing 787 that caught fire on Jan. 7, 2013, at Boston's Logan International Airport. It?s been nearly a quarter of a century since the last big jump in battery technology. As 21st century technology strains to be ever faster, cleaner and cheaper, the battery, an invention from more than 200 years ago keeps holding it back. It's why electric cars aren't clogging the roads and why Boeing's new ultra-efficient 787 Dreamliners aren't flying high. (AP Photo/National Transportation Safety Board)

FILE - In a Sept. 1, 1966 file photo, a model looks at the Sinclair Micro vision set, a pocket size television set designed by Clive Sinclair that can go anywhere and claims to be the world's smallest TV, at Earls Court, London. The rectangular face plate of the cathode tube has a diagonal measurement of two inches. It?s been nearly a quarter of a century since the last big jump in battery technology, which led to the lithium ion. As 21st century technology strains to be ever faster, cleaner and cheaper, the battery, an invention from more than 200 years ago keeps holding it back. (AP Photo, File)

FILE - In a Jan. 4, 1998 file photo, General Motors unveils the EV1 Parallel Hybrid vehicle at the North American International Auto Show in Detroit. It?s been nearly a quarter of a century since the last big jump in battery technology. As 21st century technology strains to be ever faster, cleaner and cheaper, the battery, an invention from more than 200 years ago keeps holding it back. It's why electric cars aren't clogging the roads and why Boeing's new ultra-efficient 787 Dreamliners aren't flying high. (AP Photo/Osamu Honda, File) JAPAN OUT

FILE - In a Oct. 25, 1940 file photo, F. Hans, mechanic of Frankfort-on-Main, tests the battery on an electrically driven bicycle device he has constructed to help save gasoline in the Reich in Germany. The bicycle is run by a 0.4 horsepower electric motor which receives its current from an 8-volt 60-ampere battery. It?s been nearly a quarter of a century since the last big jump in battery technology. As 21st century technology strains to be ever faster, cleaner and cheaper, the battery, an invention from more than 200 years ago keeps holding it back. It's why electric cars aren't clogging the roads and why Boeing's new ultra-efficient 787 Dreamliners aren't flying high. (AP Photo, File)

(AP) ? As 21st century technology strains to become ever faster, cleaner and cheaper, an invention from more than 200 years ago keeps holding it back. It's why electric cars aren't clogging the roads and why Boeing's new ultra-efficient 787 Dreamliners aren't flying high.

And chances are you have this little invention next to you right now and probably have cursed it recently: the infernal battery.

Boeing is the first company to make extensive use in an airliner of technology's most advanced battery ? lithium ion. But a Jan. 7 battery fire aboard a Dreamliner in Boston, followed by a similar meltdown in Japan, led authorities around the world to ground the fleet this month, highlighting a longstanding safety problem that engineers have struggled with.

In 2006 and 2007, more than 46 million cellphone batteries and 10 million laptop batteries ? all lithium ion ? were recalled because of the risk of overheating, short-circuiting and exploding. Additional safety features have been installed since then on lithium ion batteries used in consumer electronics.

As for the electric car industry, lithium ion batteries have proved to have two major drawbacks: They are costly, and they do not allow automobiles to go far enough between rechargings. A123, a maker of lithium ion batteries for electric cars, went bankrupt last year because of poor demand and high costs after receiving a $249 million federal grant.

Lithium ion batteries, which store more energy at a higher voltage and a lighter weight than earlier types, represent the most recent big jump in battery technology. And that took place nearly a quarter of a century ago.

"We need to leapfrog the engineering of making of batteries," said Lawrence Berkeley National Lab battery scientist Vince Battaglia. "We've got to find the next big thing."

But none of the 10 experts who talked to The Associated Press said they know what that big thing will be yet, or when it will come.

"If you crack it ... it'll change the world," said Carnegie Mellon University materials science professor Jay Whitacre.

Batteries are so crucial to a greener energy future that the Obama administration has spent more than $2 billion to jump-start the advanced battery industry, including setting up what some experts say is a mini-Manhattan Project for batteries.

To make the next breakthrough, researchers will have to master complex chemistry, expensive manufacturing, detailed engineering, a variety of different materials, lengthy testing, stringent safety standards and giant cost problems. It involves dealing with liquids and solids, metals and organic chemicals, and things that are in between, said Glenn Amatucci, director of the Energy Storage Research Group at Rutgers University.

"We're dealing with a system that you can imagine is almost alive. It's almost breathing," Amatucci said. "Trying to understand what's happening within these batteries is incredibly complex."

One reason the battery is the slowpoke of the high-tech highway is that it has conflicting functions. Its primary job is to store energy. But it's also supposed to discharge power, lots of it, quickly. Those two jobs are at odds with each other.

"If you want high storage, you can't get high power," said M. Stanley Whittingham, director of the Northeast Center for Chemical Energy Storage. "People are expecting more than what's possible."

On the commercial market, lithium ion batteries are generally ones small enough to fit into cellphones. But to power bigger items ? from a Prius to a 787 ? they get grouped together, increasing the juice they store and provide. That also increases the safety risk, experts say. The lithium ion battery that caught fire in a Boeing 787 weighed 63 pounds and was 19 inches long.

"You can't get around the fundamental thing is that lithium ion batteries are stuffed full of flammable liquid," Whitacre said.

Even one-in-a-million problems with lithium ion batteries can result in many fires because there are billions of them in use now, with dozens sometimes stacked together in a single device.

Experts say lithium ion batteries are more dangerous because their electrolyte, the liquid that allows ions to move between electrodes in the battery, is more flammable than the substance in older type batteries. Those older types include the lead-acid batteries in most cars and the nickel cadmium batteries that are often in video equipment and power tools.

Still, MIT materials science and engineering professor Gerbrand Ceder and others said the safety problems can be fixed.

Change doesn't come often in the battery field.

"The big advances in battery technology happen rarely. It's been more than 200 years and we have maybe five different successful rechargeable batteries," said George Blomgren, a former senior technology researcher at Eveready and now a private battery consultant. "It's frustrating."

Alessandro Volta ? for whom the volt is named ? invented the first useful battery in 1800. That was long before other breakthrough inventions like the internal combustion engine, telephone, car, airplane, transistor, computer and Internet. But all of those developments have seemed to evolve faster than the simple battery.

The lead-acid car battery "has been around for 150 years more or less," Whitacre said. "This is a remarkable testament to first how robust that chemistry is and how difficult change is."

Battery experts are split over what's next. Some think the lithium ion battery can be tinkered with to get major efficiency and storage improvements. Amatucci said he thinks we can get two to three times more energy out of future lithium ion batteries, while others said minor chemical changes can do even more.

But just as many engineers say the lithium ion battery has run its course.

"With the materials in the current lithium ion battery, we are definitely plateaued," Blomgren said. "We're waiting for something to come along that really does the job."

There are all sorts of new type batteries being worked on: lithium-air, lithium-sulfur, magnesium, sodium-ion.

"Right now it's a horse race," Blomgren said. "There's deficiencies in every technology that's out there. Each one of them requires a major solution."

One of the nation's best hopes for a breakthrough, said Battaglia, is John Goodenough, the man responsible for the 1979 breakthrough that led the first commercial lithium ion battery in 1991. He will receive the National Medal of Science at the White House next month.

Goodenough is 90.

"I'm working on it," Goodenough, an engineering professor at the University of Texas at Austin, said Tuesday. "I'm optimistic in a sense that I'm willing to keep working on it. I think we can do some interesting things."

___

Online:

Department of Energy's Joint Center for Energy Storage Research: http://www.jcesr.org

___

Seth Borenstein can be followed at http://twitter.com/borenbears

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/495d344a0d10421e9baa8ee77029cfbd/Article_2013-01-22-Battery%20Breakdown/id-b4b399847a3c4a9090f9f8018f1f8c56

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Dana Home Inspections Earns Two Service Awards - in Roswell Patch

Awards reflect company?s consistently high level of customer service.

Dana Home Inspections, a local Roswell small business, has earned the 2012 Angie?s List Super Service Award and was also named a Best of 2012 winner in Home Inspectors on Kudzu.com.

?We?re proud to be recognized in such a way by the two top service rating companies in the country,? said Scott Dana, owner of Dana Home Inspections. ?Our commitment to high-quality inspections using infrared technology is what sets us apart from other inspection companies.?

?It?s a select group of companies rated on Angie?s List that can claim the exemplary customer service record of being a Super Service Award winner,? said Angie?s List Founder Angie Hicks. ?Our standards for the Super Service Award are quite high. The fact that Dana Home Inspections earned this recognition speaks volumes about its dedication providing great service to its customers.?

?Consumers value companies who appreciate their business and provide superior service. We wanted to create an open forum where the best companies could be recognized by Kudzu users,? said Fran Wills, General Manager of Kudzu.

Angie?s List Super Service Award 2012 winners have met strict eligibility requirements, including earning a minimum number of reports, an excellent rating from their customers and abiding by Angie?s List operational guidelines.

Over 5 million businesses competed in the Best of 2012 competition across 30 categories, and winners were awarded based on the highest number of votes received on Kudzu.com.?

?

Angie?s List helps consumers have happy transactions with local service professionals in more than 550 categories of service, ranging from home improvement to health care. More than 1.5 million paid households use Angie?s List to gain unlimited access to local ratings, exclusive discounts, the Angie?s List magazine, and the Angie?s List complaint resolution service.

Kudzu helps consumers research and evaluate services and choose highly rated providers in their area. Kudzu.com features expert videos, business profiles, consumer reviews and 30,500 money-saving deals for homeowners in every major U.S. city. Kudzu.com is owned by Cox Search Inc., a subsidiary of Cox Enterprises, a leading communications, media and automotive services company. Cox's businesses include Cox Communications, Manheim, AutoTrader.com and Cox Media Group. For more information, visit http://www.kudzu.com

Source: http://roswell.patch.com/announcements/dana-home-inspections-earns-two-service-awards

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Tuesday, January 22, 2013

Tiny fossils hold answers to big questions on climate change: Research explores 12,000 year fossil record

Jan. 22, 2013 ? The western Antarctic Peninsula is one of the fastest warming regions on the planet, and the fastest warming part of the Southern Hemisphere.

Scientists have debated the causes of this warming, particularly in light of recent instrumental records of both atmospheric and oceanic warming from the region. As the atmosphere and ocean warm, so the ice sheet (holding an equivalent of 5 metres of global sea level rise, locked up in ice) becomes vulnerable to collapse.

Now research led by Cardiff University published in Nature Geoscience has used a unique 12,000 year long record from microscopic marine algae fossils to trace glacial ice entering the ocean along the western Antarctic Peninsula.

The study has found that the atmosphere had a more significant impact on warming along the western Antarctic Peninsula than oceanic circulation in the late Holocene (from 3500-250 years ago).

This was not the case prior to 3500 years ago, and is not the case in the modern environment. The study has also shown that this late Holocene atmospheric warming was cyclic (400-500 year long cycles) and linked to the increasing strength of the El Ni?o -- Southern Oscillation phenomenon (a climate pattern centred in the low latitude Pacific Ocean) demonstrating an equatorial influence on high latitude climate.

Dr Jennifer Pike, School of Earth and Ocean Sciences said: "Our research is helping to understand the past dynamic behaviour of the Antarctic Peninsula Ice Sheet. The implications of our findings are that the modern observations of ocean-driven warming along the western Antarctic Peninsula need to be considered as part of a natural centennial timescale cycle of climate variability, and that in order to understand climate change along the Antarctic Peninsula, we need to understand the broader climate connections with the rest of the planet."

Ice derived from land has a very distinctive ratio of oxygen isotopes. This research is the highest resolution application in coastal Antarctic marine sediments of a technique to measure the oxygen isotope ratios of microscopic marine algae fossils (diatom silica). When a large amount of glacial ice is discharged into the coastal ocean, this alters the oxygen isotope ratio of the sea water that the marine algae are living in. This creates a clear imprint in the fossils that reveals the environmental conditions of the time. The scientists used the oxygen isotope ratio of the fossils to reconstruct the amount of glacial ice entering the coastal ocean in the past 12,000 years, and to determine whether the variations in the amount of ice being discharged were the result of changes in the ocean or atmospheric environment.

Professor Melanie Leng, from the British Geological Survey and Chair of Isotope Geosciences in the Department of Geology, University of Leicester, said: "Technologically the analysis of the oxygen isotope composition of diatom silica is extremely difficult, the British Geological Survey is one of a very few research organisations in the world that can undertake this type of analysis. For this research project the methodology has been developed over the last five years with the specific aim of investigating the different amounts of melting in the polar regions. It's fair to say we are world leading pioneers in this technique."

The research is co-authored with Cardiff University by the universities of Nottingham, Leicester and the British Geological Survey and was funded by the Natural Environment Research Council (NERC).

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Story Source:

The above story is reprinted from materials provided by Cardiff University.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Jennifer Pike, George E. A. Swann, Melanie J. Leng, Andrea M. Snelling. Glacial discharge along the west Antarctic Peninsula during the Holocene. Nature Geoscience, 2013; DOI: 10.1038/ngeo1703

Note: If no author is given, the source is cited instead.

Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_science/~3/xvHtXnFH3XI/130122122411.htm

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Evidence mounts for role of mutated genes in development of schizophrenia

Jan. 22, 2013 ? Johns Hopkins researchers have identified a rare gene mutation in a single family with a high rate of schizophrenia, adding to evidence that abnormal genes play a role in the development of the disease.

The researchers, in a report published in the journal Molecular Psychiatry, say that family members with the mutation in the gene Neuronal PAS domain protein 3 (NPAS3) appear at high risk of developing schizophrenia or another debilitating mental illnesses.

Normally functioning NPAS3 regulates the development of healthy neurons, especially in a region of the brain known as the hippocampus, which appears to be affected in schizophrenia. The Johns Hopkins researchers say they have evidence that the mutation found in the family may lead to abnormal activity of NPAS3, which has implications for brain development and function.

"Understanding the molecular and biological pathways of schizophrenia is a powerful way to advance the development of treatments that have fewer side effects and work better than the treatments now available," says study leader Frederick C. Nucifora Jr., Ph.D., D.O., M.H.S., an assistant professor of psychiatry and behavioral sciences at the Johns Hopkins University School of Medicine. "We could definitely use better medicines."

Along with environmental factors, it is widely believed that many genes play some role in causing schizophrenia, a disease characterized by a variable combination of hallucinations, delusions, impaired cognition and a loss of drive and initiative. The disorder strikes an estimated seven in every 1,000 adults in the United States. While the Johns Hopkins experiments to date show that the NPAS3 mutation is rare, Nucifora says learning as much as possible about the biological role of NPAS3 will likely lead to a better understanding of how other genes contribute to the development of schizophrenia, even in the absence of the NPAS3 mutation.

For the study, Nucifora and his team used blood samples to search the DNA of 34 people with schizophrenia or a related condition, schizoaffective disorder. All 34 were members of families in which more than one person had the disease. The investigators were specifically looking for NPAS3 mutations -- previous research suggested it could be involved in schizophrenia -- and found it in one of the families.

By analyzing blood samples from that single family -- two parents and four adult children -- they found that the mother, who has schizophrenia, her two children with schizophrenia, and her child with major depression all had the mutant version of NPAS3. The NPAS3 gene provides instructions for the production of a protein that contains 933 amino acids. The altered gene led to a single flaw: a valine was switched to an isoleucine. Nucifora says it is not yet known how this single mutation affects the function or structure of NPAS3. A possible hint comes from the finding of other investigators that a change from valine to isoleucine in a protein known as APP is linked to Alzheimer's disease.

Nucifora cautions that, by itself, finding a mutation in a single family with mental illness doesn't establish the altered gene as the cause of the illness. Nucifora and his colleagues therefore set out to determine whether the mutation plays any role in the function of NPAS3, which serves as a master switch in cells, controlling the fate of many other genes involved in brain development and metabolism.

To do that, Nucifora and his colleagues grew neurons with either normal or mutated copies of NPAS3 in a dish, and found that the healthy neurons grew nice long extensions, a process that typically allows them to make good connections with other cells and is therefore critical for brain function. In neurons with the mutated gene, the extensions were abnormally short.

Other genes believed to be involved in mental illness also have been found to disrupt the growth of longer neuronal extensions.

"We showed that the mutation does change the function of NPAS3, with potentially harmful effects in neurons," he says. "The next step is to figure out exactly how the genetic disruption alters neuronal function, and how these abnormal neurons influence the broader function of the brain."

Nucifora and his team are now working to create a mouse with the NPAS3 mutation. "If this mutation in NPAS3 is indeed important for human disease, then we should detect abnormalities in the neurons of mice with mutant NPAS3, and the mice should have impairments in learning, memory and social behavior," he says.

The research was supported by the Brain & Behavior Research Foundation NARSAD Young Investigator Grant, the Milton and Tamar Maltz Family Foundation and the Hatten S. Yoder III Memorial Fellowship.

Other Johns Hopkins researchers involved in the study include Lan Yu, Ph.D.; Nicolas Arbez, Ph.D.; Leslie G. Nucifora, Ph.D.; Gabrielle L. Sell, B.S.; Christopher A. Ross, M.D., Ph.D.; and Russell L. Margolis, M.D.

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Story Source:

The above story is reprinted from materials provided by Johns Hopkins Medicine.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. L Yu, N Arbez, L G Nucifora, G L Sell, L E DeLisi, C A Ross, R L Margolis, F C Nucifora. A mutation in NPAS3 segregates with mental illness in a small family. Molecular Psychiatry, 2013; DOI: 10.1038/mp.2012.192

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/mind_brain/child_development/~3/nGXTi5RPaag/130122101338.htm

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Russians starts evacuating nationals from Syria

MASNAA, Lebanon (AP) ? Key Syrian ally Russia began evacuating its citizens from the country on Tuesday as the civil war gathered momentum in the capital Damascus with intense fighting around the international airport.

The evacuation was the strongest sign yet of Moscow's waning confidence in the ability of its ally President Bashar Assad to hold onto power. The U.N. chief said Tuesday that a diplomatic conclusion to the war seems unlikely.

U.S. State Department spokeswoman Victoria Nuland said the Russian evacuations indicate "the continued deterioration of the security situation and the violence that Assad is leading against his own people."

Four buses carrying about 80 people, mostly women and children, crossed out of the country over land into neighboring Lebanon in the early afternoon. They were bound for the Lebanese capital Beirut to fly home in two planes that Russia sent. They apparently were not flown directly home out of Damascus because of the fighting around the airport there.

Russian announced the beginning of the evacuations on Monday, saying it would take out 100 nationals. The Russian Foreign Ministry says there are tens of thousands of Russians living in Syria. Many of them are Russian women married to Syrian men.

The officials said thousands more evacuations could follow ? possibly by both air and sea.

Russia has been Assad's main ally since the Syrian uprising began in March 2011, selling arms, providing technical support and, along with China, using its veto power in the U.N. Security Council to shield Damascus from international sanctions over the Syrian regime's brutal crackdown on dissent.

But in recent months, Russia has started distancing itself from Assad. President Vladimir Putin said last month that he understands Syria needs change and that he was not protecting the Syrian ruler.

The Russians entered Lebanon at the Masnaa border crossing, where an official from their embassy in Beirut was waiting for them.

Some inside the buses closed the curtains so they would not be seen by journalists waiting at the border. Most refused to comment and those who did speak said only they were going home to visit relatives.

Jodie, an 8-year-old girl traveling from Damascus with her sister and her Syrian father said she was going to Moscow to see her mother, who is Russian. Jodie and her 4-year-old sister Nadine spoke briefly to reporters when they got off the bus to get their passports stamped at the border.

"I used to hear the shelling, but I was not scared," said Nadine. "I would close my eyes."

Officials at the Russian Embassy in Damascus said they have several thousand citizens registered as living in Syria. The officials, speaking on condition of anonymity because they were not authorized to talk to the media, said some of the people who were being evacuated Tuesday have lost their houses and need Russian government assistance to leave.

The officials downplayed the evacuation effort, denying that they are assisting their nationals' departures from Syria because of the deteriorating security situation.

One of the officials, who identified herself only as the embassy's head of protocol, said the government was simply responding to those who had asked for help in leaving Syria, suggesting they were mostly Russians living in areas where the fighting is fiercest.

"It's their personal desire to leave Syria," said the official. She noted that thousands of Russians were still in Syria.

In Moscow, Deputy Foreign Minister Andrei Denisov dismissed reports that the evacuations were the beginning of a Russian exodus from Syria. He told media there Russian planes landed in Beirut to deliver humanitarian aid at the Syrian government's request, and would take home those who wanted to leave.

"There is no plan to take everyone out," Denisov said. "Since the planes have arrived there, and some people with children want to leave, we are ready to take them out."

As the evacuation got under way, Syrian government forces and rebels battled in the suburbs of Damascus and elsewhere.

The Britain-based Syrian Observatory for Human Rights said clashes between opposition fighters and troops were concentrated in the areas around the capital, including along the road linking it to the international airport.

Persistent fighting along the airport road has prompted regional and international airlines to suspend flights to Damascus in recent weeks, although Syrian officials maintain that the airport remains open.

International diplomacy has done little to ease Syria's crisis, which according to the U.N. has claimed more than 60,000 lives since March 2011.

U.N. Secretary-General Ban Ki-moon said he didn't see "much prospect of resolution" by diplomacy.

At his first news conference of the year, Ban noted the worsening humanitarian conditions inside Syria and for those who have fled to neighboring countries.

For months, special envoy Lakhdar Brahimi, who represents the U.N. and the Arab League, has been pushing for a cease-fire and the formation of a transitional government ? with little apparent progress.

Ban said he and Brahimi reached a bleak conclusion after talks Monday.

"Our shared assessment is that we are still a long way from getting the Syrians together," he said.

____

Associated Press writers Albert Aji in Damascus, Syria, Vladimir Isachenkov in Moscow and Bradley Klapper in Washington contributed to this report.

Source: http://news.yahoo.com/russians-starts-evacuating-nationals-syria-195353057.html

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